Computational Chemistry Principal Research Scientist (Computational Drug Design) Job at Vertex Pharmaceuticals, Boston, MA

emVOMFl6Z2ZVNTNNdC9hMDJPYjU5Y3owWEE9PQ==
  • Vertex Pharmaceuticals
  • Boston, MA

Job Description

Vertex Pharmaceuticals seeks a computational chemist to lead drug design initiatives using molecular modeling, cheminformatics, and AI methods. The role involves advancing hit/lead identification programs, mentoring junior scientists, and collaborating across discovery teams in Boston on a hybrid basis.

Responsibilities

  • Apply computational chemistry methods to accelerate drug candidate discovery and design
  • Provide scientific leadership across discovery programs and guide computational approaches
  • Partner with medicinal chemists to generate design hypotheses and drive experimental decisions
  • Evaluate and advance AI-enabled approaches for molecular design and prediction
  • Mentor junior scientists and establish computational best practices

Requirements

  • Ph.D. in Computational Chemistry or equivalent with 6+ years drug design experience
  • Expertise in structure-based design and small-molecule optimization
  • Proficiency with commercial and open-source molecular modeling software
  • Programming skills in Python and data analysis capabilities
  • Experience applying modern AI computational methods to drug discovery
  • Strong interpersonal, communication, and presentation abilities

Compensation: $144,800 - $217,200 base

Job Tags

Similar Jobs

Gap Inc

Textile Print Designer - Gap Factory KB Sleep Job at Gap Inc

 ...systems to develop repeats, colorways, and scale variations of both purchased and original artwork. You will collaborate closely with Design, Product Development, Merchandising, and cross-functional partners to deliver compelling, brand-right print assortments that... 

Right to the City Alliance

Tenant Organizer — Tierras Comunitarias Job at Right to the City Alliance

 ...facilitate a culture of collective care. We are a member-led organization, established in this formation in May 2020, carrying a 25-year...  ...referrals move in both directions. Internal Operations & Professional Development Participate in CPC staff meetings every two weeks... 

10X Health System

Registered Nurse PRN Job at 10X Health System

 ...after hours/weekend on call mobile services COMMITMENT TO DIVERSITY As an equal opportunity employer committed to meeting the needs...  ..., sexual orientation, or disability, and actively foster inclusion in all forms both within our company and across interactions with... 

Viterbo University

Adjunct Professor - Religious Studies and Theology Job at Viterbo University

Viterbo University is seeking a pool of qualified applicants for possible temporary part-time teaching assignments. These positions are filled on an as needed basis and are on-going recruitments. Assignments may include day, evening and weekend courses and may be in -person...

Goodhue Boat Company

Experienced Marine Technician Job at Goodhue Boat Company

 ...a unique and memorable experience for our customers. This position will assist the Service Manager in ensuring the success of the Marina at our Smith Mountain Lake property!Position OverviewAs a Marine Technician, you will work alongside experienced technicians...