Principal Research Scientist I, Process Chemistry (Biocatalysis) Job at AbbVie, North Chicago, IL

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  • AbbVie
  • North Chicago, IL

Job Description

AbbVie seeks a Principal Research Scientist I with deep biocatalysis expertise to develop enzymatic processes for active pharmaceutical ingredient synthesis. The role involves enzyme engineering, directed evolution, and AI/ML integration to advance process chemistry across multiple drug modalities.

Responsibilities

  • Develop and implement biocatalytic strategies to address complex synthetic challenges in API process development
  • Engineer enzymes through recombinant DNA, protein expression, and directed evolution to improve activity and selectivity
  • Apply AI/ML tools, bioinformatics, and high-throughput experimentation to accelerate enzyme optimization
  • Lead or participate in process development and characterization projects across small molecules, peptides, and antibody-drug conjugates
  • Author technical reports, patents, publications, and present scientific findings at internal and external forums

Requirements

  • Bachelor's, Master's, or PhD in organic chemistry with 14+, 12+, or 6+ years experience respectively
  • Demonstrated hands-on expertise in biocatalysis including enzyme screening and synthetic applications
  • Proficiency in recombinant DNA techniques and heterologous protein expression
  • Experience with high-throughput experimentation platforms and data analysis workflows
  • Ability to apply AI/ML and data science approaches to chemical synthesis problems
  • Proven experience innovating chemical and automation technologies
  • Scientific leadership with strong interpersonal and communication skills

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